Abdominal aortic aneurysm as an IgG4‐related disease
| Autor: | L Voska, P Zdrahal, L Sedlackova, P Stadler, M Prucha, P Sedivy, P Prokopova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Immunology Plasma Cells IgG4‐related disease Pathogenesis Inflammation/Inflammatory disease 03 medical and health sciences 0302 clinical medicine Aneurysm Hypergammaglobulinemia parasitic diseases medicine Immunology and Allergy Humans skin and connective tissue diseases Aorta Aged Retrospective Studies IgG4 biology integumentary system business.industry fungi Original Articles Middle Aged medicine.disease Abdominal aortic aneurysm 030104 developmental biology Immunoglobulin G biology.protein histopathology IgG4-related disease Histopathology Original Article Female diagnostic value Immunoglobulin G4-Related Disease Antibody Vasculitis business aortic abdominal aneurysm 030215 immunology Aortic Aneurysm Abdominal |
| Zdroj: | Clinical and Experimental Immunology |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | Summary The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4+ plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1·35 g/l. In five of the patients, the concentration of serum IgG4 was lower than 1·20 g/l, with the number of IgG4+ plasma cells being higher than 50/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis. |
| Databáze: | OpenAIRE |
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