Factors predictive of nephropathy in DCCT Type 1 diabetic patients with good or poor metabolic control
| Autor: | Georges Krzentowski, Pierre Lefebvre, Adelin Albert, Liying Zhang |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Time Factors Adolescent Endocrinology Diabetes and Metabolism Gastroenterology Nephropathy Diabetic nephropathy Endocrinology Risk Factors Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Diabetic Nephropathies Survival analysis Glycated Hemoglobin business.industry Proportional hazards model medicine.disease Diabetes Mellitus Type 1 Metabolic control analysis Regression Analysis Female business Body mass index Kidney disease |
| Zdroj: | Diabetic Medicine. 20:580-585 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1046/j.1464-5491.2003.00986.x |
| Popis: | Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) ≥ 40 mg/24 h] from baseline covariates in Type 1 diabetic patients with either good or poor metabolic control (MC). Methods Based on material from the Diabetes Control and Complications Trial study (n = 1441), patients were considered as under good or poor MC if their HbA1c mean level up to last visit fell in the lowest (≤ 6.9%) or highest (≥ 9.5%) quintile of the overall HbA1c distribution, respectively. Prevalence cases of nephropathy were excluded from the study. Survival analysis and Cox regression were applied to the data. Results Among patients with good MC (n = 277), 15% had developed nephropathy at the end of the study. Conversely, among patients with poor MC (n = 268), the proportion without the complication was 52%. When adjusting for MC, time to diabetic nephropathy was related to age (P |
| Databáze: | OpenAIRE |
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