Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides
| Autor: | Filomena Rossi, Luisa Ronga, Diego Tesauro, Filippo Prencipe, Carlo Diaferia |
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| Přispěvatelé: | Prencipe, F., Diaferia, C., Rossi, F., Ronga, L., Tesauro, D. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
peptide targeting micelles media_common.quotation_subject precision medicine Pharmaceutical Science Peptide 02 engineering and technology Review 010402 general chemistry 01 natural sciences Micelle Analytical Chemistry QD241-441 Therapeutic index Drug Delivery Systems In vivo Drug Discovery Animals Humans Physical and Theoretical Chemistry media_common chemistry.chemical_classification Organic Chemistry 021001 nanoscience & nanotechnology Combinatorial chemistry nanomedicine 0104 chemical sciences chemistry Chemistry (miscellaneous) Cancer cell Drug delivery drug delivery Molecular Medicine Nanomedicine 0210 nano-technology Peptides |
| Zdroj: | Molecules Molecules, Vol 26, Iss 4049, p 4049 (2021) |
| ISSN: | 1420-3049 |
| Popis: | Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can facilitate cellular intake. This review focuses on micelles achieved by self-assembling or mixing peptide-grafted surfactants or peptide-decorated amphiphilic copolymers. Nanovectors loaded with hydrophobic or hydrophilic cytotoxic drugs or with gene silence sequences and externally functionalized with natural or synthetic peptides are described based on their formulation and in vitro and in vivo behaviors. |
| Databáze: | OpenAIRE |
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