Cardioprotective efficacy of dinitrosyl iron complex with L-cysteine in rats in vivo

Autor:	E. I. Chazov, O. V. Tskitishvili, Anatoly F. Vanin, L. I. Serebryakova, O. I. Pisarenko, I. M. Studneva
Rok vydání:	2008
Předmět:	medicine.medical_treatment Ischemia Hemodynamics Vasodilation Biology Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Blood pressure Mean blood pressure In vivo medicine Myocardial infarction General Agricultural and Biological Sciences Saline
Zdroj:	Scopus-Elsevier
ISSN:	1608-3059 1062-3590
DOI:	10.1134/s1062359008010147
Popis:	The effect of dinitrosyl iron complex (DNIC) with L-cysteine on the hemodynamic indices and the size of myocardial infarction, which was induced by 40-min regional ischemia and subsequent 60-min reperfusion, have been studied in rats in vivo. Intravenous bolus injection of DNIC (3.1 μmol/kg body weight in 0.5 ml saline) was performed before regional ischemia; the control group was administered the same volume of saline. DNIC administration significantly decreased the mean blood pressure throughout the experiment. DNIC reduced the duration of cardiac arrhythmias to 170 ± 10 s as against 445 ± 30 s in control. The myocardial infraction size significantly decreased in the DNIC group compared to control (38.0 ± 1.4 and 48.0 ± 3.9% of the area at risk, respectively; p < 0.05). A combination of the vasodilatory effect of DNIC with the reduction of the damaging effect of cardiac ischemia and reperfusion encourage the development of hypotensive and antiischemic drugs on this class of NO donors.
Databáze:	OpenAIRE
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