1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors

Autor:	Letizia Trincavelli, Pier Luigi Ferrarini, Gino Giannaccini, Gabriella Maria Pia Ortore, Adriano Martinelli, Giuseppe Saccomanni, Laura Betti, Tiziana Cavallini, Clementina Manera, Tiziano Tuccinardi
Rok vydání:	2005
Předmět:	Models Molecular Receptor Adenosine A2A Molecular model Stereochemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Drug Discovery medicine Animals Humans adenosine receptor Naphthyridines Molecular Biology Bicyclic molecule Chemistry Organic Chemistry Hydrogen Bonding Adenosine Adenosine receptor In vitro medicine.anatomical_structure Molecular Medicine Cattle Selectivity Nucleus medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 15:4604-4610
ISSN:	0960-894X
Popis:	A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A1AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A2AAR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a133645ea79b3bc6ee3bd3da8907a70e https://doi.org/10.1016/j.bmcl.2005.06.064 Zobrazit plný text záznamu Full Text from ScienceDirect