Clear Cell Papillary Renal Cell Carcinoma and Renal Angiomyoadenomatous Tumor
| Autor: | Gabriella Nesi, Guido Sauter, Andreas G. Nerlich, Hans-Ulrich Schildhaus, Martina Storz, Nikolaus GaBler, Peter Schraml, Adriana von Teichman, Rainer Grobholz, Falko Fend, Karl-Friedrich Deml, Helmut E. Gabbert, Eva Comperat, Joseph V. Bonventre, Benoit Lhermitte, Seife Hailemariam, Ruth Knüchel, Thomas Rüdiger, Barbara Fleige, Holger Moch, Raoul Hinze |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty TFE3 Biology urologic and male genital diseases Article Pathology and Forensic Medicine Diagnosis Differential Renal cell carcinoma medicine Humans Carcinoma Renal Cell kidney clear cell papillary renal cell cancer cytokeratin 7 VHL renal angiomyoadenomatous tumor clear cell renal cell carcinoma Aged Kidney medicine.diagnostic_test Middle Aged Clear cell papillary renal cell carcinoma medicine.disease Immunohistochemistry Kidney Neoplasms 3. Good health Clear cell renal cell carcinoma medicine.anatomical_structure Renal Angiomyoadenomatous Tumor Female Surgery Anatomy Clear cell Fluorescence in situ hybridization |
| Zdroj: | American Journal Surgical Pathology |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000000456 |
| Popis: | Clear cell papillary renal cell carcinoma (ccpRCC) and renal angiomyoadenomatous tumor (RAT) share morphologic similarities with clear cell (ccRCC) and papillary renal cell carcinoma (pRCC). It is a matter of controversy whether their morphologic, immunophenotypic and molecular features allow the definition of a separate renal carcinoma entity. The aim of our project was to investigate specific renal immunohistochemical biomarkers involved in the hypoxia-inducible factor pathway and mutations in the VHL gene to clarify the relationship between ccpRCC and RAT. We investigated 28 ccpRCC and 9 RAT samples by immunohistochemistry using 25 markers. VHL gene mutations and allele losses were investigated by Sanger sequencing and fluorescence in situ hybridization (FISH). Clinical follow-up data were obtained for a subset of the patients. No tumor recurrence or tumor-related death was observed in any of the patients. Immunohistochemistry and molecular analyses led to the reclassification of three tumors as ccRCC and TFE3 translocation carcinomas. The immunohistochemical profile of ccpRCC and RAT samples was very similar but not identical, differing from both ccRCC and pRCC. Especially, the parafibromin and hKIM-1 expression exhibited differences in ccpRCC/RAT compared with ccRCC and pRCC. Genetic analysis revealed VHL mutations in 2/27 (7%) and 1/7 (14%) ccpRCC and RAT samples, respectively. FISH analysis disclosed a 3p loss in 2/20 (10 %) ccpRCC samples. ccpRCC and RAT have a specific morphologic and immunohistochemical profile but they share similarities with the more aggressive renal tumors. Based on our results, we regard ccpRCC/RAT as a distinct entity of renal cell carcinomas. |
| Databáze: | OpenAIRE |
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