Endothelial function in patients with critical and non-critical limb ischemia undergoing endovascular treatment
| Autor: | Andrzej Belowski, Rafał Januszek, Iwona Gregorczyk-Maga, Paweł Kaczmarczyk, Paweł Maga, Stefan Chlopicki, Marzena Frołow |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Percutaneous Endothelium medicine.medical_treatment Revascularization Carotid Intima-Media Thickness Amputation Surgical Peripheral Arterial Disease Ischemia Risk Factors Internal medicine medicine Humans In patient Prospective Studies Endovascular treatment Adverse effect business.industry Critical limb ischemia Peripheral body regions medicine.anatomical_structure Treatment Outcome Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Kardiologia polska. 79(7-8) |
| ISSN: | 1897-4279 |
| Popis: | Background: Critical limb ischemia (CLI) is the most advanced stage of peripheral arterial disease. CLI patients, compared to non-CLI, achieve worse treatment outcomes and generate higher costs. Aims: The aim of the study was to compare endothelial function and clinical outcomes in CLI and non-CLI patients after percutaneous transluminal angioplasty (PTA). Methods: In this prospective, follow-up study, 30 CLI patients and 40 non-CLI patients underwent PTA. Endothelial function was assessed based on flow mediated dilatation (FMD), reactive-hyperemia index (RHI), while the ankle-brachial index, toe-brachial index and the Rutherford scale were used for peripheral artery disease progression evaluation. The results were assessed before PTA, as well as 1, 3, 6 and 12 months after the procedure. Results: There were no differences at the baseline regarding to endothelial function between both groups. Neither FMD nor RHI changed after PTA in any of the groups, although there was a difference in median RHI value between CLI and non-CLI patients regarding the 1st and 6th month of the follow-up (RHI6–RHI1 = 0.08 in CLI and –0.15 in non-CLI; P = 0.01). The larger baseline intima-media thickness (IMT) in the CLI group allowed to predict a greater number of re-intervention (P = 0.01) and major adverse event rates (P = 0.03). CLI patients presented larger decrease in the Rutherford scale compared to non-CLI (P |
| Databáze: | OpenAIRE |
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