Oxytocin decreases cocaine taking, cocaine seeking, and locomotor activity in female rats
| Autor: | Carmela M. Reichel, Shannon M. Ghee, Kah-Chung Leong, Ronald E. See, Luyi Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty media_common.quotation_subject Drug-Seeking Behavior Self Administration Oxytocin Locomotor activity Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Sex Factors Cocaine Internal medicine medicine Animals Pharmacology (medical) media_common Pharmacology Dose-Response Relationship Drug Addiction Extinction (psychology) Treatment efficacy Rats Psychiatry and Mental health Dose–response relationship 030104 developmental biology Endocrinology Female Cues Psychology Self-administration 030217 neurology & neurosurgery Locomotion Clinical psychology medicine.drug Cocaine seeking |
| Popis: | Oxytocin has been shown to decrease cocaine taking and seeking in male rats, suggesting potential treatment efficacy for drug addiction. In the present study, we extended these findings to the assessment of cocaine seeking and taking in female rats. Further, we made direct comparisons of oxytocin's impact on cocaine induced locomotor activity in both males and females. In females, systemic oxytocin (0.3, 1.0, 3.0 mg/kg) attenuated lever pressing for cocaine during self-administration and oxytocin (1.0 mg/kg) attenuated cue-induced cocaine seeking following extinction. Cocaine increased baseline locomotor activity to a greater degree in females relative to males. Oxytocin (0.1, 0.3, 1.0, and 3.0 mg/kg) reduced cocaine-induced locomotor activity in females, but not significantly in males. These data illustrate sex similarities in oxytocin's attenuation of cocaine seeking, but sex differences in cocaine-induced locomotor effects. While reductions in cocaine seeking cannot be attributed to a reduction in locomotor activity in males, attenuation of locomotor function cannot be entirely ruled out as an explanation for a decrease in cocaine seeking in females suggesting that oxytocin's effect on cocaine seeking may be mediated by different mechanisms in male and females. |
| Databáze: | OpenAIRE |
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