Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection
| Autor: | Vahid Ganjalizadeh, Matt Hamblin, Nafiz Amin, Holger Schmidt, Aaron R. Hawkins |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Opacity business.industry Physics::Optics Waveguide (optics) Article Atomic and Molecular Physics and Optics Optofluidics Electronic Optical and Magnetic Materials law.invention Biophotonics Planar Interference (communication) law Optoelectronics Electrical and Electronic Engineering business ARROW waveguide Excitation |
| Zdroj: | IEEE Photonics Technol Lett |
| ISSN: | 1941-0174 1041-1135 |
| Popis: | Optofluidic sensors have enabled single molecule sensing using planar, waveguide dependent multi-spot fluorescence excitation. Here, we demonstrate a new approach to single-particle fluorescence sensing using free-space, top-down illumination of liquid-core antiresonant reflecting optical waveguide (ARROW) devices using two different multi-spot excitation techniques. First, the liquid core ARROW waveguide is excited with a focused beam through a slit pattern milled into an opaque aluminum film, showing comparable performance for single bead fluorescence detection as in-plane, multi-mode interference waveguide based excitation. The second top-down illumination technique images the spot pattern from a Y-splitter SiO2 waveguide chip directly onto the detection device for efficient power utilization and circumventing the need for an opaque cover, producing a further $2.7\times $ improvement in signal-to-noise ratio. The two top-down approaches open up new possibilities for chip-based optical particle sensing with relaxed alignment tolerances. |
| Databáze: | OpenAIRE |
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