Hypoxia-related molecules HIF-1α, CA9, and osteopontin
| Autor: | Pınar Uyar Göçün, Ozge Petek Erpolat, G. Akyol, G. Ozgun, Muge Akmansu |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Turkey medicine.medical_treatment Sensitivity and Specificity Targeted therapy Young Adult Antigens Neoplasm Risk Factors Glioma Biomarkers Tumor Prevalence medicine Humans Radiology Nuclear Medicine and imaging Osteopontin Carbonic Anhydrase IX Survival rate Survival analysis Aged Carbonic Anhydrases biology Brain Neoplasms business.industry Reproducibility of Results Middle Aged Hypoxia (medical) Carbonic Anhydrase 9 Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Survival Analysis Cell Hypoxia Survival Rate Oncology Cancer research biology.protein Immunohistochemistry Female medicine.symptom business |
| Zdroj: | Strahlentherapie und Onkologie. 189:147-154 |
| ISSN: | 1439-099X 0179-7158 |
| Popis: | A high expression of hypoxia-inducible factor-1 alpha (HIF)-1α, carbonic anhydrase 9 (CA9), and osteopontin appears to be a strong prognostic indicator in many malignancies; however, their role is unclear in high-grade gliomas. HIF-1α, CA9, and osteopontin levels in tissue specimens of 92 patients with high-grade glioma were evaluated by immunohistochemistry. Patients with a high expression of cytoplasmic and nuclear HIF-1α, CA9, and osteopontin had significantly shorter overall survival. The expression results of these markers were combined to form a hypoxic profile, and high hypoxic scores (expression of two or three markers) were significantly correlated to poorer overall survival. In multivariate analysis, high hypoxic score-1 (cytoplasmic HIF-1α, CA9, and osteopontin) was the only independent negative prognostic factor for survival (p = 0.028). Our results showed that a combination of hypoxic markers is more robust than a single marker for predicting survival in high-grade glioma. It may be necessary to utilize the hypoxic score in selecting patients for targeted therapy in the future. |
| Databáze: | OpenAIRE |
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