In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi
| Autor: | Ming-Rung Tsai, Tuan-Shu Ho, Chih-Wei Lu, Yu-Hung Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Letter optical coherence microscopy Biomedical Engineering Junctional nevus 01 natural sciences 010309 optics Biomaterials Optical coherence tomography In vivo 0103 physical sciences Biopsy medicine Nevus Humans melanocytic nevus skin and connective tissue diseases Melanoma Nevus Pigmented medicine.diagnostic_test integumentary system business.industry Cell Differentiation Compound nevus Melanocytic nevus JBO Letters medicine.disease Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials cellular resolution in vivo imaging business Preclinical imaging Tomography Optical Coherence |
| Zdroj: | Journal of Biomedical Optics |
| ISSN: | 1560-2281 |
| Popis: | Significance: Melanocytic nevi represent the most common dermal melanocytic lesions in humans. Nevus is typically diagnosed clinically with the naked eye or with dermoscopy. However, it is essential to identify the type of nevus by invasive biopsy for histopathological examination. The use of noninvasive imaging tools can be used to evaluate the types of nevi to reduce unnecessary excisions of benign entities. Aim: To evaluate the feasibility of using en face and cross-sectional full-field optical coherence tomography (FF-OCT) in differentiation of melanocytic nevi that can facilitate the reduction of unnecessary excisions of benign entities. Approach: Dual-mode Mirau-type FF-OCT for cross-sectional imaging (B-scan) and en face imaging were used to distinguish the types of nevi. Results: Although the B-scan reveals the distribution of melanosomes, users can set a specific depth of the en face image to explore the morphology of surrounding skin cells instantly. According to the locations of nevus nests, the different types of nevi, including junction nevus and compound nevus, can be identified using this dual-mode FF-OCT system. Conclusions: Combining B-scan and en face imaging in vivo FF-OCT enables the examination and navigation of skin tissues in real time and in three dimensions. |
| Databáze: | OpenAIRE |
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