ABSORPTION, METABOLISM AND DISTRIBUTION OF [14C]-O-METHYLDOPA AND [14C]-l-DOPA AFTER ORAL ADMINISTRATION TO RATS
| Autor: | Leonor Rivera-Calimlim |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Metabolite Administration Oral Pharmacology chemistry.chemical_compound Oral administration Internal medicine medicine Animals Pharmacokinetics Carbon Radioisotopes cardiovascular diseases Methyldopa Tissue distribution Phenylacetates Brain Chemistry Chemistry Stomach Metabolism Dihydroxyphenylalanine Rats Intestines medicine.anatomical_structure Endocrinology medicine.drug |
| Zdroj: | British Journal of Pharmacology. 50:259-263 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1974.tb08570.x |
| Popis: | 1 The absorption, tissue distribution, and metabolism of [14C]-O-methyldopa were compared with those of [14C]-L-DOPA after oral administration to rats. 2 Total radioactivity in the plasma and brain of rats treated with [14C]-O-methyldopa was significantly higher (2 fold and 30-50 fold, respectively) than that of rats treated with [14C]-L-DOPA. 3 Total radioactivity in the gut washings and intestinal tissue 2 h after oral administration was significantly higher in rats treated with [14C]-L-DOPA than in rats treated with [14C]-O-methyldopa. The reverse was observed in the stomach tissues. 4 Peripheral metabolism of [14C]-O-methyldopa was much lower than that of [14C]-L-DOPA; the major metabolite of [14C]-O-methyldopa in the plasma is L-DOPA, whereas L-DOPA is mainly metabolized to phenylcarboxylic acids. |
| Databáze: | OpenAIRE |
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