Protective effect against gastric mucosa injury of a sulfated agaran from Acanthophora spicifera
| Autor: | Judith P.A. Feitosa, Guilherme Julião Zocolo, Renan Oliveira Silva Damasceno, Venicios G. Sombra, Glauber Cruz Lima, Ana Lúcia Ponte Freitas, Fernando G. Nascimento, Eliane Marinho Soriano, Marcellus H.L.P. Souza, Lindauro C. Pereira Júnior, Regina C.M. de Paula, Lorena Mara A. Silva, Samara Rodrigues Bonfim Damasceno Oliveira, Francisco Diego da Silva Chagas |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Polymers and Plastics 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Lipid peroxidation chemistry.chemical_compound Mice Sulfation Acanthophora spicifera Polysaccharides Materials Chemistry Gastric mucosa medicine Animals Stomach Ulcer biology Chemistry Sulfates Organic Chemistry Stomach Glutathione 021001 nanoscience & nanotechnology Malondialdehyde biology.organism_classification Mucus Molecular biology 0104 chemical sciences Agar Oxidative Stress medicine.anatomical_structure Cytoprotection Gastric Mucosa Rhodophyta 0210 nano-technology Oxidative stress |
| Zdroj: | Carbohydrate polymers. 261 |
| ISSN: | 1879-1344 |
| Popis: | In this study, a polysaccharide from marine alga Acanthophora spicifera (PAs) was isolated and structurally characterized. Its protective potential against chemically-induced gastric mucosa injury was evaluated. The gel permeation chromatography experiments and spectroscopy spectrum showed that PAs is a sulfated polysaccharide with a high molecular mass (6.98 × 105g/mol) and degree of sulfation of 1.23, exhibiting structural characteristic typical of an agar-type polysaccharide. Experimental results demonstrated that PAs reduced the hemorrhagic gastric injury, in a dose-dependent manner. Additionally, PAs reduced the intense gastric oxidative stress, measured by glutathione (GSH) and malondialdehyde (MDA) levels. PAs also prevented the reduction of mucus levels adhered to the gastric mucosa, promoted by the aggressive effect of ethanol. In summary, the sulfated polysaccharide from A. spicifera protected the gastric mucosa through the prevention of lipid peroxidation and enhanced the defense mechanisms of the gastric mucosa, suggesting as a promising functional food as gastroprotective agent. |
| Databáze: | OpenAIRE |
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