Condensed thienopyrimidines. II. Synthesis and gastric antisecretory activity of thiazole and polymethylene condensed thienopyrimidine derivatives
| Autor: | Mitsuko Kobayashi, Keiichi Ito, Keiichi Tabata, Fukumi Hiroshi, Kazuo Endo, Mitsuo Sugiyama, Toshiaki Sakamoto |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Thiophosgene Oxazolidine Chemical Phenomena Stereochemistry Rats Inbred Strains Pyrimidinones General Chemistry General Medicine Anti-Ulcer Agents Rats Chemistry Structure-Activity Relationship chemistry.chemical_compound chemistry Drug Discovery Lactam Animals Moiety Structure–activity relationship Methylene Thiazole |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 37:2122-2131 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Thiazolo[3,2-a]thieno[3,2-d]-, [3,4-d]- and [2,3-d]pyrimidin-5-one derivatives (6, 11 and 16), and polymethylene condensed thieno[3,2-d]-, [3,4-d]- and [2,3-d]pyrimidin-5-one derivatives (19-21), in which the oxygen atom of the oxazolidine moiety in 3 was replaced by a sulfur atom or methylene groups, were synthesized and evaluated for gastric antisecretory activity in pylorus-ligated rats. The structure-activity relationships of these compounds are discussed. |
| Databáze: | OpenAIRE |
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