Antifungal Monoterpene Derivatives from the Plant Endophytic FungusPestalotiopsis foedan
| Autor: | Bing-Yang Zhang, Xiao-Long Yang, Dan Xu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Phytophthora
Antifungal Agents food.ingredient Stereochemistry Monoterpene Molecular Conformation Antifungal drug Bioengineering Microbial Sensitivity Tests 010402 general chemistry 01 natural sciences Biochemistry Plant use of endophytic fungi in defense Structure-Activity Relationship chemistry.chemical_compound food Candida albicans Endophytes Pestalotiopsis Molecular Biology Botrytis chemistry.chemical_classification Dose-Response Relationship Drug Xylariales biology 010405 organic chemistry Chemistry Absolute configuration General Chemistry General Medicine biology.organism_classification 0104 chemical sciences Propanoic acid Monoterpenes Molecular Medicine Lactone |
| Zdroj: | Chemistry & Biodiversity. 13:1422-1425 |
| ISSN: | 1612-1872 |
| DOI: | 10.1002/cbdv.201600114 |
| Popis: | A new monoterpene lactone, (1R,4R,5R,8S)-8-hydroxy-4,8-dimethyl-2-oxabicyclo[3.3.1]nonan-3-one (1), along with one related known compound, (2R)-2-[(1R)-4-methylcyclohex-3-en-1-yl]propanoic acid (2), were isolated from the liquid culture of the plant endophytic fungus Pestalotiopsis foedan obtained from the branch of Bruguiera sexangula. The structure and absolute configuration of 1 were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the optical rotation (OR) and 13 C-NMR. Both compounds exhibited strong antifungal activities against Botrytis cinerea and Phytophthora nicotianae with MIC values of 3.1 and 6.3 μg/ml, respectively, which are comparable to those of the known antifungal drug ketoconazole. Compound 2 also showed modest antifungal activity against Candida albicans with a MIC value of 50 μg/ml. |
| Databáze: | OpenAIRE |
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