Cefuroxime - A new cephalosporin antibiotic
| Autor: | R. B. Sykes, D. M. Ryan, P. W. Muggleton, Cynthia H. O'callaghan, R. D. Foord |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.drug_class
Antibiotics Cephalosporin medicine.disease_cause Haemophilus influenzae Microbiology Drug Incompatibility Drug Discovery medicine Humans Furans Cephalosporinase Cephalosporin Antibiotic Pharmacology Bacteria biology Blood Proteins Enterobacter biology.organism_classification Cephalosporins Kinetics Neisseria gonorrhoeae Intramuscular injection Cefuroxime Protein Binding medicine.drug |
| Zdroj: | The Journal of Antibiotics. 29:29-37 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.29.29 |
| Popis: | Cefuroxime is a new broad spectrum cephalosporin antibiotic for administration by injection. It is stable to most beta-lactamases. It is active against gram-positive organisms, including penicillinase-producing staphylococci, and has wide activity against gram-negative bacilli including Enterobacter and many strains of indole-positive Proteus spp. The substance is also highly active against Haemophilus influenzae and Neisseria gonorrhoeae. Studies on human volunteers showed that it produced high, long-lasting blood levels with virtually complete recovery of unchanged antibiotic in the urine. No evidence of toxicity due to cefuroxime was found. Slight, short-lived pain followed intramuscular injection, and the compound was well tolerated intravenously. |
| Databáze: | OpenAIRE |
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