The possible role of substance P in the allergic reaction, based on two different provocation models
| Autor: | Jörg Kleine-Tebbe, R. Rathsack, K. Nieber, Tilo Brunnée, Claus R. Baumgarten, A. Witzel, P. Oehme, Gert Kunkel |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Allergy Allergic reaction Nasal Provocation Tests Inflammatory response Immunology Provocation test Substance P Histamine Release Bronchial Provocation Tests chemistry.chemical_compound medicine Hypersensitivity Immunology and Allergy Humans Inflammation business.industry General Medicine respiratory system medicine.disease respiratory tract diseases Nasal Mucosa Bronchial provocation chemistry Female Neprilysin Airway business Bronchoalveolar Lavage Fluid |
| Zdroj: | International archives of allergy and applied immunology. 94(1-4) |
| ISSN: | 0020-5915 |
| Popis: | It was shown in two different provocation models (nasal and bronchial provocation) that substance P (SP) may play an important role in the neurogenic inflammatory response in upper and lower airway disease. (1) Pretreatment with SP augments the antigen challenge response of the nasal mucosa. (2) The baseline bronchoalveolar lavage (BAL) concentrations of SP are elevated 8-fold in allergies (pollen asthma) as compared with normals, even outside of season. (3) The SP concentration in BAL increases significantly (p |
| Databáze: | OpenAIRE |
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