Association between CYP1B1 Gene Polymorphisms and Risk Factors and Susceptibility to Laryngeal Cancer
| Autor: | Peng-Ju Yu, Man-Jie Jiang, Wei Chen, Ze-Qing Li, Wei-Guan Chen, Quan-Lin Feng |
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| Rok vydání: | 2015 |
| Předmět: |
Male
China medicine.medical_specialty Pathology Alcohol Drinking Genotype CYP1B1 Biology Real-Time Polymerase Chain Reaction Lower risk Polymorphism Single Nucleotide Gastroenterology Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Allele Laryngeal Neoplasms Alleles Aged Polymorphism Genetic Smoking Haplotype Case-control study General Medicine Middle Aged Laryngeal Neoplasm Haplotypes Case-Control Studies Cytochrome P-450 CYP1B1 Mutation Lab/in Vitro Research Steroid 11-beta-Hydroxylase Female Gene polymorphism |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.893084 |
| Popis: | Background The aim of this study was to investigate the association between polymorphism of the cytochrome P450 1B1 (CYP1B1) gene, a metabolic enzyme gene, and the susceptibility to laryngeal cancer among the Chinese Han population. Material/Methods In a case-control study, we investigated polymorphisms in the CYP1B1 gene (rs10012, rs1056827, and rs1056836) with a real-time quantitative polymerase chain reaction (PCR) assay (TaqMan). The study was conducted with 300 Chinese Han patients with laryngeal cancer and 300 healthy Chinese Han subjects in a control group. We also studied the interactions between genetic polymorphism and risk factors such as smoking and alcohol consumption in the pathogenesis of laryngeal cancer. Results There were statistically significant differences in the distributions of the rs1056827 and rs1056836 genotypes between the 2 groups. Regarding rs1056827, carriers of the T allele had a significantly higher risk of laryngeal cancer than the G-allele carriers (OR=1.4339, 95% CI: 1.1268–1.8247; P=0.0034). The difference was still statistically significant after adjusting for factors such as age, sex, smoking, and drinking (adjusted OR=1.743, 95% CI: 1.124–3.743, P |
| Databáze: | OpenAIRE |
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