Verification of the new grading scale for ocular chronic graft-versus-host disease developed by the German-Austrian-Swiss consensus conference on chronic GVHD
| Autor: | Daniel Wolff, Horst Helbig, Christiane Blecha, Barbara Holler, Tina Dietrich-Ntoukas, Regine Vogt, Daniela Weber, Ernst Holler |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Activities of daily living Conjunctiva Adolescent Eye Diseases Graft vs Host Disease Disease Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Cornea Internal medicine Germany Medicine Humans Transplantation Homologous Grading (education) Aged Hematology business.industry Hematopoietic Stem Cell Transplantation General Medicine Middle Aged medicine.disease eye diseases United States Surgery Consensus Development Conferences NIH as Topic medicine.anatomical_structure Graft-versus-host disease Austria Chronic Disease 030221 ophthalmology & optometry Female business Grading scale Switzerland 030215 immunology Follow-Up Studies |
| Zdroj: | Annals of hematology. 95(3) |
| ISSN: | 1432-0584 |
| Popis: | The purpose of the study was to validate a recently proposed new grading system for ocular manifestations of chronic graft-versus-host disease (cGVHD). Diagnosis of cGVHD was based on the NIH consensus criteria. In addition, a grading scale was applied, which has been developed by the German-Austrian-Swiss Consensus Conference on Clinical Practice in cGVHD. Sixty-six patients (male n = 46, female n = 20, mean age 48 years) with ocular cGVHD were included. Application of the proposed Consensus Conference grading revealed inflammatory activity in all patients with mild (33 %), moderate (44 %), or severe inflammation (23 %). Clinical scoring by the NIH scoring system showed that 6 % of patients had mild symptoms; 59 % of patients had moderate dry eye symptoms partially affecting activities of daily living, without vision impairment; and 35 % of patients had severe dry eye symptoms significantly affecting daily activities. Clinical characterization and grading by the Consensus Conference grading scale revealed that ocular cGVHD (1) frequently leads to severe ocular surface disease based on impaired function of the lacrimal glands and involvement of cornea, conjunctiva, and lids; (2) is mostly associated with ongoing inflammatory activity; (3) often leads to functional impairment and reduced quality of life; and (4) is associated with an increased risk for severe, sight-threatening complications. |
| Databáze: | OpenAIRE |
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