Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke
| Autor: | Gordon J. Harris, Rebecca E. Green, Loc Duyen D. Pham, Natalia S. Rost, Eng H. Lo, Allison J. Dipietro, Paul E. Milbury, Svetlana Lorenzano, Matthew B. Maas, Ken Arai, Karen L. Furie, Angel T. Som, Ona Wu, Hua Li, Fabricio O. Lima, Jeffrey B. Blumberg, Tijy Thankachan, Steven K. Feske, Muhib Khan |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Brain Infarction
Male medicine.medical_specialty Ischemia Brain damage 030204 cardiovascular system & hematology medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Prospective Studies Stroke Aged Aged 80 and over Advanced and Specialized Nursing F2-Isoprostanes medicine.diagnostic_test biology business.industry C-reactive protein Magnetic resonance imaging Odds ratio Middle Aged medicine.disease Confidence interval Oxidative Stress C-Reactive Protein F2-isoprostanes Matrix metalloproteinase 2 Oxidative stress Biomarkers Brain Injuries Female biology.protein Cardiology Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Popis: | Background and Purpose— Oxidative stress is an early response to cerebral ischemia and is likely to play an important role in the pathogenesis of cerebral ischemic injury. We sought to evaluate whether hyperacute plasma concentrations of biomarkers of oxidative stress, inflammation, and tissue damage predict infarct growth (IG). Methods— We prospectively measured plasma F2-isoprostane (F2-isoP), urinary 8-oxo-7,8-dihydro-2′-deoxyguoanosine, plasma oxygen radical absorbance capacity assay, high sensitivity C reactive protein, and matrix metalloproteinase 2 and 9 in consecutive patients with acute ischemic stroke presenting within 9 hours of symptom onset. Patients with baseline diffusion-weighted magnetic resonance imaging and follow-up diffusion-weighted imaging or computed tomographic scan were included to evaluate the final infarct volume. Baseline diffusion-weighted imaging volume and final infarct volume were analyzed using semiautomated volumetric method. IG volume was defined as the difference between final infarct volume and baseline diffusion-weighted imaging volume. Results— A total of 220 acute ischemic stroke subjects were included in the final analysis. One hundred seventy of these had IG. Baseline F2-isoP significantly correlated with IG volume (Spearman ρ=0.20; P =0.005) and final infarct volume (Spearman ρ=0.19; P =0.009). In a multivariate binary logistic regression model, baseline F2-isoP emerged as an independent predictor of the occurrence of IG (odds ratio, 2.57; 95% confidence interval, 1.37–4.83; P =0.007). In a multivariate linear regression model, baseline F2-isoP was independently associated with IG volume (B, 0.38; 95% confidence interval, 0.04–0.72; P =0.03). Conclusions— Elevated hyperacute plasma F2-isoP concentrations independently predict the occurrence of IG and IG volume in patients with acute ischemic stroke. If validated in future studies, measuring plasma F2-isoP might be helpful in the acute setting to stratify patients with acute ischemic stroke for relative severity of ischemic injury and expected progression. |
| Databáze: | OpenAIRE |
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