Host and environmental factors enhancing carcinogenesis in the respiratory tract
| Autor: | R Jamasbi, P Nettesheim, D C Topping |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Acquired diseases
Aging Lung Neoplasms Biology Environment Sulfides Toxicology medicine.disease_cause Occupational safety and health Epithelium Nickel medicine Animals Humans Benzopyrenes Lung cancer Vitamin A Respiratory Tract Infections Pharmacology Immunosuppression Therapy Host (biology) Cancer Asbestos medicine.disease Respiratory Tract Neoplasms medicine.anatomical_structure Immunology Etiology Carcinogens Gases Carcinogenesis Respiratory tract |
| Zdroj: | Annual review of pharmacology and toxicology. 21 |
| ISSN: | 0362-1642 |
| Popis: | Particularly in deaing with occupational lung cancer, it is often difficult to identify the major causative agent(s) or cofactor(s) in the complex work environment. The problem is further compounded by various factors that may predispose individuals or groups of individuals to the development of cancer. Among the factors that have to be considered are the genetic control of drug metabolism, and a number of genetic aberrations. Similarly, various acquired diseases and physiological or nutritional states have been implicated in certain types of cancer, though precise interrelationships have not been defined. Over the past 10 years, our laboratory has been engaged in studies concerned with the pathogenesis of lung cancer, with particular attention given to the possible interaction of multiple endogenous and exogenous factors. Those studies and major contributions made by other investigators which might have a bearing on the problem of the multifactor etiology of lung cancer are reviewed. Experiments relating to modification of host susceptibility and studies concerned with the interaction of environmental or occupational agents are discussed. |
| Databáze: | OpenAIRE |
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