Smoking-related DNA adducts in human gastric cancers
| Autor: | G.W. Dyke, R. Hall, R.C. Garner, J.L. Craven |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Adduct Tumour tissue chemistry.chemical_compound Stomach Neoplasms medicine Humans Nucleotide Risk factor Phosphorus Radioisotopes Aged chemistry.chemical_classification Aged 80 and over business.industry Stomach Smoking Cancer DNA Neoplasm Middle Aged medicine.disease medicine.anatomical_structure Oncology chemistry Gastric Mucosa Cancer research Female business DNA |
| Zdroj: | International journal of cancer. 52(6) |
| ISSN: | 0020-7136 |
| Popis: | DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the 32P-post-labelling method. Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/10(8) nucleotides to 60 adducts/10(8) nucleotides. In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non-smokers. These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text