| Autor: |
Taufieq Ridlo Makhmud, Rohman, Mohammad Saifur, Sargowo, Djanggan, Suwarniaty, Renny, Nugroho, Faris Wahyu, Bambang Kusbandono, Citra Tarannita, Ratih Kusumawardani, Sasmojo Widito, Heny Martini |
| Rok vydání: |
2020 |
| DOI: |
10.6084/m9.figshare.12084474 |
| Popis: |
Background : Rheumatic heart disease (RHD) contributed to a large number of proportion amoung cardiovascularproblems in developing county, especially Indonesia. Secondary prophylaxis method using intramuscularinjection of Benzathin Penicillin-G (BPG) has been known as the most effective strategy in the prevention of RHD.However, whether this prevention method also resulting in prevention of disease severity in Indonesian patientsremained to be examined.Objectives : This study aimed to assess the difference of rheumatic valve severity in Indonesian pediatric patientsbetween adequate and poor adherence to secondary prophylaxis by using intramuscular BPG injection.Methods : This cross-sectional study was conducted at Pediatric Cardiology Department of Saiful Anwar GeneralHospital from November 2018 to June 2019. Patients with documented history of RHD were included. Frequencyof intramuscular BPG injection during the last one year was recorded. Adherence was measured using the proportionof days covered (PDC) and adequate adherence was defined as PDC ≥0.90. The severity of RHD wasassessed based on the severity of the mitral and / or aortic valve using echocardiography. Bivariate analysis andmultivariate logistic regression analysis was used to identify characteristics associated with rheumatic valveseverity.Results : A significant difference of rheumatic mitral and/or aortic valve severity was observed between adequateadherence compared to poor adherence group (p = 0.016). Rheumatic mitral and/or aortic valve were found tobe more severe in patients who has one or more episode of ARF recurrence (p = 0.003). Multivariate logisticregression analysis demonstrated that adherence to secondary prophylaxis within the last 1 year has the strongestinfluence on the severity of rheumatic mitral and/or aortic valve (p = 0.049; OR 7.20).Conclusion : The adherence to secondary prophylaxis has the strongest related the rheumatic valve severitycompared to other factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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