Adiponectin is Inversely Associated with Insulin Resistance in Adolescents with Nonalcoholic Fatty Liver Disease
| Autor: | Guanghui Liu, Bin Liu, Huan Zheng, Zhiling Li |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Adipokine Gastroenterology Body Mass Index Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Nonalcoholic fatty liver disease medicine Humans Insulin Immunology and Allergy Child Triglycerides Adiponectin business.industry nutritional and metabolic diseases medicine.disease Female Insulin Resistance business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 22:631-639 |
| ISSN: | 1871-5303 |
| Popis: | Background: Insulin Resistance (IR) is confirmed as a key feature of Nonalcoholic Fatty Liver Disease (NAFLD) in children and adolescents. Numerous studies report that adiponectin (APN) levels are inversely associated with the status of IR in adults with NAFLD. This study aimed to investigate the relationship between serum total APNand Homeostasis Model Assessment Insulin Resistance (HOMA-IR) in adolescents with NAFLD. Methods: 382 newly-diagnosed NAFLD adolescents, aged 9-16 years old, were enrolled and divided into three subgroups according to the APNtertile. Simple and multiple linear regression analyses were performed to assess the correlation between HOMA-IR and APN in boys and girls, respectively. Results: The HOMA-IR values tended to decrease in boys according to APN tertiles: 5.6(4.4-7.3) vs. 5.2(4.6-6.9) vs. 4.9(4.1-5.8) (p Conclusion: Our findings showed that APN was an independent and significant determinant for increased HOMA-IR in boys with NAFLD. Further studies are needed to explore the underlying mechanisms. |
| Databáze: | OpenAIRE |
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