Lack of effect of an acute ileal perfusion of short-chain fatty acids on glucose metabolism in healthy men
| Autor: | A. Ruskone-Fourmestraux, A. Boussairi, F. Bornet, Salwa W. Rizkalla, Gérard Slama, A. Chevalier, C. Alamowitch, F. Guyon, Josette Boillot |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Butyrate Acetates Fatty Acids Nonesterified Biology Carbohydrate metabolism Ileum Reference Values Physiology (medical) Internal medicine medicine Humans Saline chemistry.chemical_classification Insulin Metabolism Glucose clamp technique Fatty Acids Volatile Receptor Insulin Diet Perfusion Blood Glucose Endocrinology Liver chemistry Glucose Clamp Technique Propionate |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 271:E199-E204 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1996.271.1.e199 |
| Popis: | Dietary fiber intake is associated with several beneficial effects on carbohydrate metabolism. Some authors have speculated that this improvement may be due to short-chain fatty acids (SCFA) produced by the colonic fermentation of dietary fibers. To test this hypothesis, six healthy men aged 26 +/- 2 (SE) yr with a body mass index of 20.9 +/- 0.7 received on three occasions an 18-h ileal perfusion infused at a flow rate of 3.3 ml/min, containing either 90 mmol/l of SCFA (60% acetate, 25% propionate, and 15% butyrate) (A), SCFA during the first 12 h and then a saline solution (A/S), or a saline solution (S). Basal hepatic glucose production (BHGP), insulin sensitivity (3-step euglycemic-hyperinsulinic clamp), and erythrocyte insulin binding (EIB) were studied 12 h after the beginning of the ileal perfusion. There was no change in BHGP or insulin sensitivity. However, maximal EIB was significantly different: 7.1 +/- 0.1 (A), 6.8 +/- 0.1 (A/S), vs. 6.5 +/- 0.1% (S) (P = 0.03). We conclude that acute administration of SCFA does not significantly alter glucose metabolism in healthy subjects. |
| Databáze: | OpenAIRE |
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