Highly Efficient Stereocontrolled Synthesis of Danishefsky’s Taxol CD Ring Key Intermediate

Autor:	Gérard Audran, Paul Brémond, Honoré Monti
Rok vydání:	2008
Předmět:	Molecular Structure Paclitaxel Propanols Stereochemistry Chemistry Organic Chemistry Absolute configuration Stereoisomerism Docetaxel Ring (chemistry) Chemical synthesis Stereocenter Yield (chemistry) Taxoids Stereoselectivity
Zdroj:	The Journal of Organic Chemistry. 73:6033-6036
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo800913x
Popis:	Danishefsky's taxol CD ring key intermediate is synthesized in 15 steps and 11.4% overall yield from a readily available starting material. Absolute stereochemistry of the starting material and stereocontrolled steps determine the absolute configuration of the five requisite contiguous stereocenters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11b2d664d93c20378827484346ed429 https://doi.org/10.1021/jo800913x Zobrazit plný text záznamu