Association between -251A>T polymorphism in the interleukin-8 gene and oral cancer risk: A meta-analysis
| Autor: | Liping Zhang, Xin-ming Guan, Zhi-ming Wang, Chuanning Wang, Xiaoping Lin, Zhiguo Zhao, Fang Liu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Risk
medicine.medical_specialty Genotype Single-nucleotide polymorphism Subgroup analysis Biology Bioinformatics Polymorphism Single Nucleotide Gastroenterology White People Asian People Polymorphism (computer science) Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Genetic Association Studies Interleukin-8 Cancer General Medicine Odds ratio medicine.disease Confidence interval Case-Control Studies Meta-analysis Mouth Neoplasms |
| Zdroj: | Gene. 522:168-176 |
| ISSN: | 0378-1119 |
| Popis: | Background Emerging evidence showed that the most common functional polymorphism (-251A>T, rs4073) in the promoter region of the interleukin-8 (IL-8) gene is involved in the regulation of the activities of interleukin-8, thus increasing an individual's susceptibility to oral cancer; but individually published results are inconclusive. The aim of this meta-analysis was to investigate the associations between IL-8 -251A>T polymorphism and oral cancer risk. Methods The PubMed, Embase, Web of Science and CBM databases were searched for all articles published up to October 1st, 2012 that addressed IL-8 -251A>T polymorphism and oral cancer risk. Statistical analyses were performed using STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Results Six case–control studies were included with a total of 1324 oral cancer cases and 1879 healthy controls. When all available studies were pooled into the meta-analysis, the results showed that the AA and AT genotypes of IL-8 -251A>T polymorphism were associated with increased risk of oral cancer (OR = 1.23, 95% CI: 1.03–1.46, P = 0.025; OR = 1.25, 95% CI: 1.07–1.47, P = 0.006; respectively). In the subgroup analysis by ethnicity, significant associations were observed between the AA and AT genotypes of IL-8 -251A>T polymorphism and increased risk of oral cancer among Caucasian populations (OR = 1.40, 95% CI: 1.14–1.72, P = 0.001; OR = 1.29, 95% CI: 1.06–1.57, P = 0.011; respectively). However, no statistically significant associations were found between IL-8 -251A>T polymorphism and oral cancer risk among Asian populations. Conclusions Results from the current meta-analysis indicate that the AA and AT genotypes of IL-8 -251A>T polymorphism might increase the risk of oral cancer, especially among Caucasian populations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect