Paleopathological and biomolecular study of tuberculosis in a medieval skeletal collection from England
| Autor: | Douglas B. Young, AJ Legge, Simon Mays, Gordon Turner-Walker, GM Taylor |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
DNA Bacterial Male Tuberculosis Paleopathology Disease Polymerase Chain Reaction Bone and Bones Amidohydrolases law.invention Mycobacterium tuberculosis Bacterial Proteins law medicine Humans Polymerase chain reaction Mycobacterium bovis biology Osteology Middle Aged biology.organism_classification medicine.disease History Medieval DNA-Binding Proteins Repressor Proteins Ancient DNA England Type C Phospholipases Anthropology Immunology Housing Microscopy Electron Scanning Female Anatomy Transcription Factors |
| Zdroj: | American Journal of Physical Anthropology. 114:298-311 |
| ISSN: | 1096-8644 0002-9483 |
| DOI: | 10.1002/ajpa.1042 |
| Popis: | Nine human skeletons of medieval date from a rural English burial site show signs of skeletal tuberculosis. They were subject to polymerase chain reaction (PCR) assays aimed at detecting traces of DNA from infecting mycobacteria, with the purpose both of confirming the paleopathological diagnosis of tuberculosis and determining in individual cases whether disease was due to M. tuberculosis or M. bovis. In all nine cases, evidence for M. tuberculosis complex DNA was found, and in all instances it appeared that disease was due to M. tuberculosis rather than M. bovis. The significance of the findings for understanding tuberculous infection in rural agrarian communities in medieval England is discussed. |
| Databáze: | OpenAIRE |
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