New insights in pathogenic mechanism of hydroxychloroquine retinal toxicity through optical coherence tomography angiography analysis

Autor:	Lidia Remolí Sargues, Clara Monferrer Adsuara, Verónica Castro Navarro, María Luisa Hernández Garfella, Laura Hernández Bel, Catalina Navarro Palop, Javier Montero Hernández, Enrique Cervera Taulet
Rok vydání:	2022
Předmět:	Ophthalmology Humans Retinal Vessels Macula Lutea General Medicine Fluorescein Angiography Tomography Optical Coherence Hydroxychloroquine Retrospective Studies
Zdroj:	European Journal of Ophthalmology. 32:3599-3608
ISSN:	1724-6016 1120-6721
DOI:	10.1177/11206721221076313
Popis:	Introduction There is only a unique report with a small sample size studying hydroxychloroquine (HCQ) retinal toxicity with swept-source (SS) optical coherence tomography angiography (OCTA). The aim of this study was to quantify OCTA quantitative parameters in patients who underwent HCQ therapy. Methods We conducted a retrospective study. The study included 43 eyes of 22 patients taking HCQ for more than 5 years (high-risk group), 57 eyes of 29 patients taking HCQ for 5 years or less (low-risk group) and 25 eyes of 50 age-matched healthy controls. OCTA quantitative parameters (vessel density (VD) and foveal avascular zone (FAZ) area in superficial capillary plexus (SCP), middle capillary plexus (MCP), deep capillary plexus (DCP), total capillary plexus (TCP), and choriocapillaris (CC)) were recorded. Results In the low-risk group, VD in the SCP and MCP was increased compared to control group ( p value Conclusion We demonstrated an increase of VD in patients who underwent HCQ treatment, so we suggest that HCQ retinal toxicity is not vascular mediated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11836b90d53cbd8ba52fb1bb6db17fa https://doi.org/10.1177/11206721221076313 Zobrazit plný text záznamu