Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines
| Autor: | J. Andrew MacKay, Sarah F. Hamm-Alvarez, Jugal P. Dhandhukia, Jordan Despanie |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmaceutical Science Administration Ophthalmic Antineoplastic Agents Nanotechnology 02 engineering and technology Article law.invention 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems law Animals Humans chemistry.chemical_classification Tropoelastin biology Genetically engineered Polymer 021001 nanoscience & nanotechnology Small molecule Elastin Nanomedicine 030104 developmental biology chemistry Cardiovascular Diseases Drug delivery Recombinant DNA biology.protein Elastin like polypeptides Peptides 0210 nano-technology Protein trafficking |
| Zdroj: | Journal of Controlled Release. 240:93-108 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2015.11.010 |
| Popis: | Elastin-like polypeptides (ELPs) constitute a genetically engineered class of ‘protein polymers’ derived from human tropoelastin. They exhibit a reversible phase separation whereby samples remain soluble below a transition temperature (Tt) but form amorphous coacervates above Tt. Their phase behavior has many possible applications in purification, sensing, activation, and nanoassembly. As humanized polypeptides, they are non-immunogenic, substrates for proteolytic biodegradation, and can be decorated with pharmacologically active peptides, proteins, and small molecules. Recombinant synthesis additionally allows precise control over ELP architecture and molecular weight, resulting in protein polymers with uniform physicochemical properties suited to the design of multifunctional biologics. As such, ELPs have been employed for various uses including as anti-cancer agents, ocular drug delivery vehicles, and protein trafficking modulators. This review aims to offer the reader a catalogue of ELPs, their various applications, and potential for commercialization across a broad spectrum of fields. |
| Databáze: | OpenAIRE |
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