Risk factors for need of mechanical ventilation in children with Influenza A(H1N1)pdm09

Autor: Marcelo Comerlato Scotta, Rita Mattiello, Gilberto Bueno Fischer, Marcus Herbert Jones, Letícia G. Martins, Paulo José Cauduro Marostica
Jazyk: angličtina
Předmět:
Male
Pediatrics
medicine.medical_treatment
Comorbidity
chemistry.chemical_compound
Influenza A Virus
H1N1 Subtype
Pandemic
Prevalence
Medicine
Young adult
Child
Influenza A H1N1 subtype
medicine.diagnostic_test
Coinfection
Incidence (epidemiology)
lcsh:RJ1-570
Age Factors
virus diseases
Hospitalization
Treatment Outcome
Child
Preschool
Female
Insuficiência respiratória
Respiratory insufficiency
Brazil
Oseltamivir
medicine.medical_specialty
Adolescent
Criança
Influenza
Human
Humans
Pediatrics
Perinatology
and Child Health
Intensive care medicine
Retrospective Studies
Mechanical ventilation
Fatores de risco
business.industry
Influenza A subtipo H1N1
Infant
lcsh:Pediatrics
Retrospective cohort study
Length of Stay
medicine.disease
Respiration
Artificial
chemistry
Risk factors
Chronic Disease
Multivariate Analysis
Pediatrics
Perinatology and Child Health
business
Chest radiograph
Zdroj: Jornal de Pediatria, Vol 89, Iss 5, Pp 444-449 (2013)
ISSN: 0021-7557
DOI: 10.1016/j.jped.2013.01.010
Popis: Objective: The pandemic caused by influenza A(H1N1)pdm09 virus peaked between July and August of 2009 in southern Brazil, with the highest incidence in children and young adults. In the post-pandemic period, there was an increase in the incidence of cases during the winter months of 2011 and 2012 in Brazil, similar to seasonal influenza virus. Since infections due to pandemic influenza are still occurring, the present study aimed to investigate the risk factors for worse outcome in children. Methods: A retrospective cohort study was performed by reviewing the charts of hospitalized patients younger than 14 years with reverse transcription-polymerase chain reaction (RT-PCR) positive for influenza A(H1N1)pdm09 during the first pandemic wave in six Brazilian tertiary centers. Need for mechanical ventilation was defined as the severity of outcome; age, chronic diseases, bacterial and viral co-detection, chest radiograph findings, and use of oseltamivir were possible predictors. Results: In the present study, 120 patients were included. In a multivariate analysis, chronic diseases (prevalence ratio: 2.613, 95% CI: 1.267-5.386) and viral co-detection (prevalence ratio: 2.43, 95% CI: 1.203-4.905) were statistically associated with worse outcome (p
Databáze: OpenAIRE
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