Andrastins A-C, New Protein Farnesyltransferase Inhibitors Produced by Penicillium sp. FO-3929. I. Producing Strain, Fermentation, Isolation, and Biological Activities

Autor:	Seiji Kosemura, Yuzuru Iwai, Ryuji Uchida, Tomoya Kawakubo, Rokuro Masuma, Shosuke Yamamura, Satoshi Omura, Junji Inokoshi, Haruo Tanaka, Kazuro Shiomi
Rok vydání:	1996
Předmět:	Magnetic Resonance Spectroscopy Farnesyltransferase Microbial Sensitivity Tests Crystallography X-Ray High-performance liquid chromatography chemistry.chemical_compound Transferases Drug Discovery Farnesyltranstransferase Pharmacology chemistry.chemical_classification Farnesyl-diphosphate farnesyltransferase Alkyl and Aryl Transferases Chromatography Molecular Structure biology Silica gel Penicillium biology.organism_classification Androstadienes Enzyme chemistry Biochemistry Enzyme inhibitor Fermentation biology.protein
Zdroj:	The Journal of Antibiotics. 49:414-417
ISSN:	1881-1469 0021-8820
DOI:	10.7164/antibiotics.49.414
Popis:	New protein farnesyltransferase inhibitors, andrastins A-C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 microM, respectively.
Databáze:	OpenAIRE
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