Clinical and corneal microbial profile of infectious keratitis in a high HIV prevalence setting in rural South Africa
| Autor: | N.S. Khosa, James McIntyre, G.S. Baarsma, Erik Schaftenaar, Christina Meenken, Albert D. M. E. Osterhaus, Georges M. G. M. Verjans, Remco P. H. Peters, Sarah Getu |
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| Přispěvatelé: | Virology, Ophthalmology, Other Research |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Keratoconjunctivitis Infectious Male Rural Population Microbiology (medical) medicine.medical_specialty Adolescent viruses HIV Infections Infectious Keratitis medicine.disease_cause Keratitis Cornea 03 medical and health sciences South Africa Young Adult 0302 clinical medicine Medical microbiology SDG 3 - Good Health and Well-being medicine Prevalence Outpatient clinic Animals Humans Keratoconjunctivitis Aged Aged 80 and over Bacteriological Techniques Bacteria business.industry Varicella zoster virus Fungi General Medicine Middle Aged medicine.disease Dermatology Cross-Sectional Studies Infectious Diseases Herpes Zoster Ophthalmicus Immunology DNA Viral Viruses 030221 ophthalmology & optometry Original Article Female business 030217 neurology & neurosurgery Uveitis |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases, 35(9), 1403-1409. Springer-Verlag Schaftenaar, E, Peters, R P H, Baarsma, G S, Meenken, C, Khosa, N S, Getu, S, McIntyre, J A, Osterhaus, A D M E & Verjans, G M G M 2016, ' Clinical and corneal microbial profile of infectious keratitis in a high HIV prevalence setting in rural South Africa ', European Journal of Clinical Microbiology and Infectious Diseases, vol. 35, no. 9, pp. 1403-1409 . https://doi.org/10.1007/s10096-016-2677-x European Journal of Clinical Microbiology and Infectious Diseases, 35(9), 1403-1409. Springer Verlag European Journal of Clinical Microbiology & Infectious Diseases |
| ISSN: | 0934-9723 |
| Popis: | The purpose of this investigation was to determine the clinical and corneal microbial profile of infectious keratitis in a high human immunodeficiency virus (HIV) prevalence setting in rural South Africa. Data in this cross-sectional study were collected from patients presenting with symptoms of infectious keratitis (n = 46) at the ophthalmology outpatient department of three hospitals in rural South Africa. Corneal swabs were tested for herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), varicella zoster virus (VZV) and adenovirus DNA by real-time polymerase chain reaction (PCR) and for bacteria and fungi by culture. Based on clinical history, disease characteristics and laboratory results, 29 (63 %) patients were diagnosed as viral keratitis, including 14 (48 %) viral keratitis cases complicated by bacterial superinfection, and 17 (37 %) as bacterial keratitis. VZV and HSV-1 DNA was detected in 11 (24 %) and 5 (11 %) corneal swabs, respectively. Among clinically defined viral keratitis cases, a negative viral swab was predominantly (93 %) observed in cases with subepithelial inflammation and was significantly associated with an increased duration of symptoms (p = 0.003). The majority of bacteria cultured were Gram-positive (24/35), including Staphylococcus epidermidis and S. aureus. Viral aetiology was significantly associated with a history of herpes zoster ophthalmicus (p |
| Databáze: | OpenAIRE |
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