PRELIMINARY MONOCENTRIC RESULTS OF BIOLOGICAL CHARACTERISTICS OF PREGNANCY ASSOCIATED BREAST CANCER
| Autor: | Fernando Bozza, Cristina Ghiotto, Laura Evangelista, Raffaello Grigoletto, Franco Barbazza, Tania Saibene, Silvia Michieletto, Giovanna Rossi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Receptor ErbB-2 medicine.medical_treatment Genes BRCA2 Genes BRCA1 Kaplan-Meier Estimate Cohort Studies Pregnancy Mastectomy Carcinoma Ductal Breast Liver Neoplasms Postpartum Period General Medicine Prognosis Receptors Estrogen Chemotherapy Adjuvant Lymphatic Metastasis Female Receptors Progesterone Pregnancy Complications Neoplastic Cohort study Adult medicine.medical_specialty Antineoplastic Agents Bone Neoplasms Breast Neoplasms Young Adult Breast cancer Internal medicine medicine Humans Radical mastectomy Retrospective Studies business.industry BRCA mutation Retrospective cohort study Genes p53 medicine.disease Radiation therapy Carcinoma Lobular Ki-67 Antigen Axilla Mutation Lymph Node Excision Surgery Lymph Nodes Neoplasm Recurrence Local business Postpartum period |
| Popis: | Purpose We performed a mono-institutional study for evaluating the biological data, such as p53, Ki67 and BRCA mutations, as well as clinical characteristics of pregnancy associated breast cancer (PABC), its therapeutic management and the prognosis in a small cohort of patients. Materials and methods We retrospectively examined 26 patients with PABC. Clinical and histopathological characteristics along with Ki67, p53 and BRCA mutations were analysed. Information about chemotherapy, surgery and radiotherapy was recovered. Data about long-term prognosis was registered and computed by Kaplan–Meier analysis. Results Of 26 patients, 17 (65%) were considered as having a locally advanced breast cancer. The majority of them (65.4%) had a ductal invasive carcinoma. Oestrogen and progesterone receptors were positive in 13 (50%) patients, resulting both negative in four (15.4%) subjects. HER-2 was positive in 5 subjects (19.2%). Ten patients underwent conservative surgery treatment, and 14 were sent to radical mastectomy (38 vs. 54%) associated with axillary lymph node dissection in 18 cases. Many patients (65%) were further treated with adjuvant chemotherapy and/or hormone therapy. Eight out of 11 patients undergoing the evaluation of BRCA mutation were positive while only 2 out of 3 patients had a mutation of p53. After a median follow-up of 110 months (range: 8.2–1227 mo.), 18 women were still alive, six patients (25%) died and two were lost. Three patients showed a loco-regional recurrence, after a median period of 26 months (range: 2–42 mo.). Distant metastases verified in six patients after a median period of 12.5 months (range: 2–108 mo.). The prognosis was less favourable in BRCA mutated patients than no-BRCA mutated group, although not statistically significant. Conclusions In women with PABC, the initial stage of disease is more advanced requiring more aggressive treatment. |
| Databáze: | OpenAIRE |
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