Bioreactor development for tissue-engineered cartilage
| Autor: | Deepak Jain, Twana Davisson, Rebecca De La Torre, Noushin Dunkelman, Al Peterson, Florence Wu |
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| Rok vydání: | 1999 |
| Předmět: |
Articular surfaces
Chemistry General Neuroscience Cartilage Tissue engineered cartilage Articular cartilage Anatomy Equipment Design Tissue repair General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Bioreactors History and Philosophy of Science Biodegradable scaffold Culture Techniques medicine Bioreactor Cell Adhesion Humans Biomedical engineering |
| Zdroj: | Annals of the New York Academy of Sciences. 875 |
| ISSN: | 0077-8923 |
| Popis: | The development of tissue engineered cartilage is emerging as a potential treatment for the repair of cartilage defects. By seeding chondrocytes onto poly-glycolic acid (PGA) biodegradable scaffolds within a convective-flow bioreactor, the synthesis of tissue-engineered articular cartilage has been recently demonstrated. The ability to cultivate and manipulate this cell-polymer construct to possess specific dimensions, as well as biochemical and biomechanical properties is critical for potential application as an in vivo therapy of damaged articular surfaces. Bioreactor design requirements for stages from research to development to commercialization are discussed. Advantages and limitations to various bioreactor designs are critiqued. These studies illustrate the ability to synthesize tissue-engineered cartilage under convective-flow conditions for potential human tissue repair. |
| Databáze: | OpenAIRE |
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