Efeito da terapia sistêmica de ozônio como um biomodulador da regeneração tecidual e da resposta inflamatória em ratos
| Autor: | Juliana Rico PIRES, Alexandre Melo KARAM, Valdir Gouveia GARCIA, Fernando Salimon RIBEIRO, Ana Emilia Farias PONTES, Cleverton Roberto de ANDRADE, Elizangela Cruvinel ZUZA |
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| Přispěvatelé: | Centro Universitário da Fundação Educacional de Barretos, Colégio Regional Bahiano, Universidade Estadual Paulista (UNESP), Cirurgião-dentista, Universidade Federal de Juiz de Fora, Universidade Federal Fluminense |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Insufflation
medicine.medical_specialty ratos cicatrização Rectum Inflammation wound healing Gastroenterology Neovascularization Ozone Internal medicine medicine inflamação business.industry Regeneration (biology) Therapeutic effect RK1-715 General Medicine Ozone therapy rats medicine.anatomical_structure inflammation Dentistry Medicine Ozônio medicine.symptom Wound healing business |
| Zdroj: | Revista de Odontologia da UNESP v.50 2021 Revista de Odontologia da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP SciELO Repositório Institucional da UNESP Revista de Odontologia da UNESP, Volume: 50, Article number: e20210046, Published: 29 OCT 2021 Revista de Odontologia da UNESP, Vol 50 (2021) |
| Popis: | Introduction Among the therapeutic effects of ozone therapy, improvement in cell metabolism and peripheral tissue oxygenation have been highlighted. Objective to evaluate the systemic effect of bio-oxidative therapy with ozone gas on wound healing. Material and method Tissue lesions with a circumference of 1.0 cm were induced in the skin on the back of 24 male Wistar rats. The animals were randomly divided into two groups: 1) Group C (control; n=12): with simulation of the application of ozone gas via the rectum and, 2) Group O3 (test; n=12): with application of ozone gas by means of rectal insufflation at a concentration of 50 µg/mL. The animals were euthanized at seven and 15 days, and samples were removed, fixed in formalin, and submitted to macroscopic, histological, and histometric analyses. Result The animals in the O3 group presented mixed inflammation at seven days, which translated into an absence of inflammation at 15 days. The C group exhibited acute inflammation on the 7th day, translating to chronic inflammation, which significantly increased from the 7th to the 15th day. The findings showed that the O3 group presented greater wound contraction (P |
| Databáze: | OpenAIRE |
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