A Systematic Relationship Between Functional Connectivity and Intracortical Myelin in the Human Cerebral Cortex
Autor: | Pierre-Louis Bazin, Arno Villringer, Daniel S. Margulies, Julia M. Huntenburg, Christine L. Tardif, Alexandros Goulas |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male Cognitive Neuroscience Rest Macaque Angular gyrus 03 medical and health sciences Cellular and Molecular Neuroscience Myelin Young Adult 0302 clinical medicine Cortex (anatomy) biology.animal Neural Pathways medicine Image Processing Computer-Assisted Humans myelin imaging cortical microstructure Myelin Sheath Cerebral Cortex Brain Mapping medicine.diagnostic_test biology Functional connectivity functional connectivity Magnetic resonance imaging Original Articles Magnetic Resonance Imaging White Matter 030104 developmental biology medicine.anatomical_structure Cerebral cortex high-resolution MRI Female Psychology Neuroscience 030217 neurology & neurosurgery Software |
Zdroj: | Cerebral Cortex (New York, NY) Cerebral Cortex |
ISSN: | 1460-2199 1047-3211 |
Popis: | Research in the macaque monkey suggests that cortical areas with similar microstructure are more likely to be connected. Here, we examine this link in the human cerebral cortex using 2 magnetic resonance imaging (MRI) measures: quantitative T1 maps, which are sensitive to intracortical myelin content and provide an in vivo proxy for cortical microstructure, and resting-state functional connectivity. Using ultrahigh-resolution MRI at 7 T and dedicated image processing tools, we demonstrate a systematic relationship between T1-based intracortical myelin content and functional connectivity. This effect is independent of the proximity of areas. We employ nonlinear dimensionality reduction to characterize connectivity components and identify specific aspects of functional connectivity that are linked to myelin content. Our results reveal a consistent spatial pattern throughout different analytic approaches. While functional connectivity and myelin content are closely linked in unimodal areas, the correspondence is lower in transmodal areas, especially in posteromedial cortex and the angular gyrus. Our findings are in agreement with comprehensive reports linking histologically assessed microstructure and connectivity in different mammalian species and extend them to the human cerebral cortex in vivo. |
Databáze: | OpenAIRE |
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