The Enhancing Effect of Fungal Immunomodulatory Protein-Volvariella Volvacea (FIP-vvo) on Maturation and Function of Mouse Dendritic Cells
| Autor: | Betty-Revon Liu, Nien-Tsu Hsieh, Dz-Chi Chen, Ching-Liang Chu, Ju-Pi Li, Jung-Chein Ma, Ren-In You, Yi-Pang Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
T cell Science CD11c Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine Immunity In vivo medicine fungal immunomodulatory proteins (FIPs) Ecology Evolution Behavior and Systematics Paleontology Volvariella volvacea Acquired immune system biology.organism_classification In vitro Cell biology 030104 developmental biology medicine.anatomical_structure FIP-vvo Space and Planetary Science dendritic cell (DC) Function (biology) 030215 immunology |
| Zdroj: | Life, Vol 11, Iss 471, p 471 (2021) Life Volume 11 Issue 6 |
| ISSN: | 2075-1729 |
| Popis: | Volvariella volvacea, also known as straw mushroom, is a common edible mushroom in Chinese cuisine. It contains many nutrients for human health. A fungal immunomodulatory protein (FIP) has been isolated from V. volvacea and named FIP-vvo. Although the regulatory effects of many FIPs on immunity have been identified, the impact of FIP-vvo in modulating dendritic cells (DCs), which play a key role to connect the innate and the adaptive immunity, is not known. In this study, we aim to study the effect of FIP-vvo on the DC maturation and function. We found that FIP-vvo slightly increased the generation of CD11c+ bone marrow-derived DC (BMDC). In addition, the surface expression of MHCII was promoted in BMDCs after the treatment of FIP-vvo, suggesting that FIP-vvo induces DC maturation. Furthermore, FIP-vvo enhanced the ability of BMDCs to activate antigen-specific T cell responses in vitro. In the in vivo study, the FIP-vvo treatment facilitated T cell response in lymph nodes. Therefore, for the first time, our data demonstrated that FIP-vvo promoted DC maturation and function and suggested that FIP-vvo could have benefits for human health by enhancing immunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|