Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in Obesity

Autor: Lorenzo Romano, Carmela Falcone, Nicola Polimeni, P. Correale, Antonino De Lorenzo, Sebastiano Macheda, Pietro Arciello, Paola Gualtieri
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
obesity
Cachexia
medicine.medical_treatment
Bed rest
Settore MED/49
lcsh:Chemistry
0302 clinical medicine
Risk Factors
fat
Medicine
Prospective Studies
030212 general & internal medicine
Medical nutrition therapy
Prospective cohort study
lcsh:QH301-705.5
Wasting
Spectroscopy
General Medicine
Middle Aged
Computer Science Applications
Liver
Female
medicine.symptom
Coronavirus Infections
Adult
CT scan
medicine.medical_specialty
diagnostic imaging
Pneumonia
Viral
Nutritional Status
030209 endocrinology & metabolism
Article
Catalysis
Inorganic Chemistry
Betacoronavirus
03 medical and health sciences
Internal medicine
Humans
Physical and Theoretical Chemistry
Muscle
Skeletal
Pandemics
Molecular Biology
Aged
liver attenuation
body composition
SARS-CoV-2
business.industry
Organic Chemistry
COVID-19
muscle wasting
lean
medicine.disease
Obesity
Malnutrition
lcsh:Biology (General)
lcsh:QD1-999
inflammation
Lean body mass
Tomography
X-Ray Computed
business
Zdroj: International Journal of Molecular Sciences
Volume 21
Issue 13
International Journal of Molecular Sciences, Vol 21, Iss 4670, p 4670 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21134670
Popis: Obesity is a characteristic of COVID-19 patients and the risk of malnutrition can be underestimated due to excess of fat: a paradoxical danger. Long ICU hospitalization exposes patients to a high risk of wasting and loss of lean body mass. The complex management precludes the detection of anthropometric parameters for the definition and monitoring of the nutritional status. The use of imaging diagnostics for body composition could help to recognize and treat patients at increased risk of wasting with targeted pathways. COVID-19 patients admitted to the ICU underwent computed tomography within 24 h and about 20 days later, to evaluate the parameters of the body and liver composition. The main results were the loss of the lean mass index and a greater increase in liver attenuation in obese subjects. These could be co-caused by COVID-19, prolonged bed rest, the complex medical nutritional therapy, and the starting condition of low-grade inflammation of the obese. The assessment of nutritional status, with body composition applied to imaging diagnostics and metabolic profiles in COVID-19, will assist in prescribing appropriate medical nutritional therapy. This will reduce recovery times and complications caused by frailty.
Databáze: OpenAIRE
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