Growth factors and myointimal hyperplasia in experimental aortic allografts
| Autor: | Antonio Cavallaro, Mario B. Guglielmi, Antonio V. Sterpetti, Bruto Randone, Alessandra Cucina, Palestini M, Francesco Stipa, Luciana Santoro-D'Angelo, Piero Proietti, Aromatario C |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Pathology Platelet-derived growth factor Isograft Basic fibroblast growth factor Organ culture myointimal hyperplasia chemistry.chemical_compound Mice medicine.artery medicine Animals Aorta Abdominal Growth Substances Aorta Vascular Patency Medicine(all) biology IL-1 business.industry Abdominal aorta Interleukin aortic allografts 3T3 Cells PDGF Aortic allografts Atherosclerosis bFGF Myointimal hyperplasia Endometrial Hyperplasia Female Interleukin-1 Mitogens Rats Rats Inbred Lew Tunica Intima Surgery chemistry cardiovascular system biology.protein atherosclerosis Cardiology and Cardiovascular Medicine business Platelet-derived growth factor receptor |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1078-5884 |
| DOI: | 10.1016/s1078-5884(97)80053-6 |
| Popis: | Objectives:To analyse the role of growth factors (platelet derived growth factor, PDGF; basic fibroblast growth factor, bFGF; interleukin 1, IL-1) in the genesis of myointimal hyperplasia in arterial allografts.Materials:Two groups of experiments were performed: isografts and allografts. The isograft group consisted of 15 inbred Lewis rats in which a 1 cm long segment of aorta was inserted as an abdominal aortic interposition graft. The aortic segments were obtained from syngenic Lewis rats. The allograft group consisted of 15 inbred Lewis rats, in which a 1 cm long segment of aorta was interposed at the abdominal aorta level. The aortic segments were obtained from allogenic Brown-Norway rats.Chief outcome measures:The animals were killed 4 weeks after surgery and were analysed by morphometric analysis (n = 3 for each group). In addition, production of PDGF, bFGF and IL-1 by aortic segments (n = 12 for each group) in organ culture was assessed.Main results:Allografts had more myointimal hyperplasia, than isografts (p < 0.05). PDGF and bFGF production, generally considered to be the cause of myointimal hyperplasia, was not increased in allografts. IL-1 production was higher in allografts (p < 0.001).Main conclusions:Myointimal hyperplasia in aortic allografts is dependent on growth factors produced by the graft itself. These growth factors are different from PDGF and bFGF that generally have been implicated in the genesis of naturally occurring myointimal hyperplasia and atherosclerosis. IL-1 may have a principal role in the genesis of myointimal hyperplasia in arterial allografts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect