Low Rap1-interacting factor 1 and sirtuin 6 expression predict poor outcome in radiotherapy-treated Hodgkin lymphoma patients
| Autor: | Katja Marin, Päivi Auvinen, Peeter Karihtala, Taina Turpeenniemi-Hujanen, Ylermi Soini, Outi Kuittinen, Hamid Bur, Kirsi-Maria Haapasaari |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
SIRT6 Adult Male Cancer Research Adolescent DNA repair Telomere-Binding Proteins lymphoma medicine.disease_cause 03 medical and health sciences Young Adult 0302 clinical medicine Rif1 Radioresistance Gene expression medicine Biomarkers Tumor Humans Sirtuins Reed-Sternberg Cells Aged Aged 80 and over biology Radiotherapy Acetylation Hematology Middle Aged medicine.disease Prognosis Hodgkin Disease Lymphoma radioresistance Survival Rate sirtuin 030104 developmental biology Histone Oncology 030220 oncology & carcinogenesis Sirtuin Immunology Cancer research biology.protein Female Neoplasm Recurrence Local Carcinogenesis Follow-Up Studies |
| Zdroj: | Leukemialymphoma. 59(3) |
| ISSN: | 1029-2403 |
| Popis: | Sirtuins (SIRTs) are a family of histone deacetylases, which widely regulate cellular metabolism and are also involved in DNA repair. Rap1-interacting factor 1 (Rif1) and O⁶-alkylguanine DNA alkyltransferase (MGMT) are DNA-repair enzymes, which may potentially be involved in resistance to treatment of classical Hodgkin lymphoma (HL). We assessed the expression levels of (previously unstudied) SIRT1, SIRT4, SIRT6, Rif1, and MGMT immunohistochemically in 85 patients with untreated classical HL. Aberrant distributions of SIRT1, SIRT4, and SIRT6 were detected in Hodgkin neoplastic Reed–Sternberg (RS) cells compared with reactive elements. Low-level expression of both Rif1 and SIRT6 predicted dismal relapse-free survival in radiotherapy-treated patients (multivariate analysis; HR 8.521; 95% CI 1.714–42.358; p = .0088). Expression levels of SIRT1, 4, and 6 were abnormally distributed in RS cells, suggesting a putative role of aberrant acetylation in classical HL carcinogenesis. Rif1 and SIRT6 may also have substantial prognostic and even predictive roles in classical HL. |
| Databáze: | OpenAIRE |
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