Effect of the SQ 14,225 and SQ 20,881 on the kallikrein-kinin system
| Autor: | J.L. Pola, A. Martinez Seeber, O. L. Catanzaro, S. B. Vila |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Captopril Proline Kallikrein kinin system Kidney urologic and male genital diseases Renal kallikrein Excretion chemistry.chemical_compound Internal medicine medicine Animals Teprotide cardiovascular diseases Pharmacology chemistry.chemical_classification Kininogen Kininogens urogenital system Rats Inbred Strains Kallikrein Angiotensin II biological factors Diuresis Rats Endocrinology Enzyme chemistry Kallikreins Oligopeptides circulatory and respiratory physiology Saralasin |
| Zdroj: | Pharmacological Research Communications. 13:927-935 |
| ISSN: | 0031-6989 |
| DOI: | 10.1016/s0031-6989(81)80064-1 |
| Popis: | Summary The inhibitors of the converting enzyme and the kininase II, SQ 14,225 and SQ 20,881, were administered chronically to normal Wistar rats to evaluate different parameters of the kallikrein-kinin system. Both drugs produced an increase in the urinary flow and kallikrein excretion. Renal kallikrein decreased and plasma kininogen increased in both experimental groups. Since similar results were obtained using saralasin, a competitive inhibitor of angiotensin II, it is postulated the possibility that the alterations observed in the kallikrein-kinin system were due to the inhibition of the renin-angiotensin system and not to the reduced activity of the kininase II. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|