Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns
| Autor: | José Luis Álvarez-Sala, Lydia Abasolo, Cristina Vadillo, Leticia Leon, Juan Angel Jover, María Jesús Rodríguez-Nieto, Dalifer Freites-Núñez, Fredeswinda Romero-Bueno, Maria Asuncion Nieto, Olga Sánchez-Pernaute |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Exacerbation Population Interstitial lung disease Arthritis Rheumatoid 03 medical and health sciences Diseases of the respiratory system 0302 clinical medicine Usual interstitial pneumonia Internal medicine medicine Risk of mortality Humans Longitudinal Studies Rheumatoid arthritis Mortality education Aged 030203 arthritis & rheumatology Aged 80 and over education.field_of_study RC705-779 business.industry Mortality rate Middle Aged respiratory system medicine.disease Survival Analysis respiratory tract diseases Pneumonia Standardized mortality ratio 030228 respiratory system Spain Multivariate Analysis Female business Lung Diseases Interstitial Tomography X-Ray Computed Research Article |
| Zdroj: | BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-9 (2021) BMC Pulmonary Medicine |
| ISSN: | 1471-2466 |
| Popis: | Background To assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality. Methods A longitudinal multicentric study was conducted in RA-ILD patients from 2005 to 2015 and followed-up until October 2018 in Madrid. Patients were included in the Neumologia-Reumatología y Enfermedades Autoinmunes Registry, from diagnosis of ILD. The main outcome was all-cause mortality. The radiographic pattern at baseline [usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), or others] was the independent variable. Covariables included sociodemographic and clinical data. Survival techniques were used to estimate MR, expressed per 1000 persons-year with their 95% confidence intervals [CI]. Cox multiple regression model was run to examine the influence of radiographic patterns on survival. SMR [CI] was calculated comparing MR obtained with MR expected in the general population of Madrid by indirect age-gender standardization. Results 47 patients were included with a follow-up 242 patients-year. There were 16 (34%) deaths, and most frequent causes were acute ILD exacerbation and pneumonia. MR was 64.3 [39.4–104.9], and 50% of the patients died at 8.3 years from ILD diagnosis. After adjusting for confounders, (UIP compared to NSIP was associated with higher mortality risk. The overall SMR was 2.57 [1.4–4.17]. Women of 60–75 years of age were the group with the highest SMR. Conclusions RA-ILD is associated with an excess of mortality compared to general population. Our results support that UIP increases the risk of mortality in RA-ILD, regardless other factors. |
| Databáze: | OpenAIRE |
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