Periconceptional Undernutrition in Sheep Affects Adult Phenotype Only in Males
| Autor: | Jane E. Harding, Anne L. Jaquiery, Mark H. Oliver, Frank H. Bloomfield, Maggie Honeyfield-Ross |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Article Subject business.industry Offspring Endocrinology Diabetes and Metabolism medicine.disease Phenotype Adipose capsule of kidney Fat mass Malnutrition lcsh:Nutritional diseases. Deficiency diseases Endocrinology Internal medicine Fetal growth Medicine Postnatal growth business lcsh:RC620-627 Food Science Research Article |
| Zdroj: | Journal of Nutrition and Metabolism Journal of Nutrition and Metabolism, Vol 2012 (2012) |
| ISSN: | 2090-0724 |
| DOI: | 10.1155/2012/123610 |
| Popis: | Periconceptional undernutrition (PCUN) in sheep alters fetal growth and metabolism and postnatal growth regulation, but effects on adult body composition are unknown. We investigated the effects of PCUN on adult phenotype. Singleton lambs of ewes fed normally (N,n=17) or undernourished before (UN-61-0 d,n=23), before and after (UN-61-30 d,n=19), or after (UN-2-30d,n=17) mating (d0) were weighed at birth, 12 weeks, and intermittently to adulthood. At the age of 3-4 years, body composition was assessed by dual-emission X-ray absorptiometry followed bypostmortemexamination. Compared with N animals, male, but not female, offspring of all UN groups had greater % fat mass (all UN versus N:9±1versus2±1%,P<0.001) and perirenal fat (544±36versus222±44 g,P=0.002), and proportionately smaller hearts (4.5±0.1versus5.2±0.2 g·kg−1), lungs (9.1±0.2versus10.6±0.5 g·kg−1), and adrenals (0.06±0.002versus0.08±0.003 g·kg−1). UN males also had larger testes (726±21versus545±32 g,P=0.007), but UN females had smaller ovaries (2.7±0.08versus3.4±0.4 g,P=0.01). Changes were independent of birth weight or postnatal growth velocity. Brief PCUN has sex-specific effects on adult phenotype, predominantly affecting males, which may contribute to adverse metabolic outcomes. |
| Databáze: | OpenAIRE |
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