Absorption, Distribution and Excretion of Phenindamine (Thephorin)

Autor:	D. L. Howie, R. E. Dailey, J. R. Parikh, E. Leong Way, Chen-yu Sung
Rok vydání:	1950
Předmět:	Gastrointestinal tract Phenindamine Pyridines business.industry Physiology Biological Transport Absorption (skin) Urine General Biochemistry Genetics and Molecular Biology Body Fluids Excretion Oral administration Medicine Distribution (pharmacology) business Feces medicine.drug
Zdroj:	Experimental Biology and Medicine. 74:394-398
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-74-17919
Popis:	SummaryPhenindamine (Thephorin) was determined in biologic material with a high degree of specificity by a modification of the Brodie methyl orange technic. Negligible amounts of phenindamine can be recovered in the urine of humans following oral administration. In studies on rats the compound appears to be rapidly absorbed from the gastrointestinal tract. The compound rapidly leaves the blood and concentrates in tissues. High concentrations of the drug were found in the lungs, liver, kidneys and brain. Extensive accumulation of phenindamine did not occur after repeated administration of the compound twice daily for 4 consecutive days. It is concluded that the compound is metabolized to a considerable extent in the body since less than 12 per cent of the total dose of phenindamine could be recovered unchanged in the urine and feces 24 hours following oral administration.We are grateful to the American Allergy Foundation and the Division of Research Grants, National Institutes of Health, U. S. Public Healt...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a103fa4c4cb8a262c63ee38054db0f8b https://doi.org/10.3181/00379727-74-17919 Zobrazit plný text záznamu