Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor

Autor:	Luisa Ciobanu, Denis Le Bihan, Boucif Djemai, Tomokazu Tsurugizawa, Clément Debacker
Rok vydání:	2020
Předmět:	Male Niacinamide Science Hippocampus 03 medical and health sciences Mice 0302 clinical medicine In vivo Thiadiazoles medicine Animals Diffusion (business) 030304 developmental biology Aquaporin 4 0303 health sciences Chemistry Brain Correction Mice Inbred C57BL medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Cerebral cortex Astrocytes Biophysics Medicine Glymphatic system 030217 neurology & neurosurgery Diffusion MRI Astrocyte
Zdroj:	PLoS ONE PLoS ONE, Vol 15, Iss 5, p e0229702 (2020)
ISSN:	1932-6203
Popis:	The Glymphatic System (GS) has been proposed as a mechanism to clear brain tissue from waste. Its dysfunction might lead to several brain pathologies, including the Alzheimer’s disease. A key component of the GS and brain tissue water circulation is the astrocyte which is regulated by acquaporin4 (AQP4), a membrane-bound water channel on the astrocytic end-feet. Here we investigated the potential of diffusion MRI to monitor astrocyte activity in a mouse brain model through the inhibition of AQP4 channels with TGN-020. Upon TGN-020 injection, we observed a significant decrease in the Sindex, a diffusion marker of tissue microstructure, and a significant increase of the water diffusion coefficient (sADC) in cerebral cortex and hippocampus compared to saline injection. These results indicate the suitability of diffusion MRI to monitor astrocytic activity in vivo and non-invasively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a102460c50ca2a687282eb9953f9e9e9 https://pubmed.ncbi.nlm.nih.gov/32584900 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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