Correlation between the alterations in the mRNA expressions of the α1-adrenoceptor and estrogen receptor subtypes in the pregnant human uterus and cervix
| Autor: | George Falkay, Zsolt Kormányos, Eszter Ducza, Béla Endre Resch |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Uterus Estrogen receptor Cervix Uteri Biology Pregnancy Receptors Adrenergic alpha-1 Internal medicine Gene expression medicine Humans RNA Messenger Cervix Estrogen receptor beta Pharmacology Estrogen Receptor alpha Reverse transcription polymerase chain reaction medicine.anatomical_structure Endocrinology Estrogen Female Estrogen receptor alpha hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Pharmacology. 528:183-187 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2005.10.050 |
| Popis: | Our present aim was to determine the association between the mRNA expressions of the estrogen and adrenoceptor subtypes in the pregnant human uterus and cervix. The presence of the mRNA expressions of all the alpha1-adrenoceptor and estrogen receptor subtypes in the uterus and cervix was proved by means of a reverse transcription polymerase chain reaction method, with a predominance of the mRNAs of the alpha1B-adrenoceptor and estrogen alpha receptors, respectively. The change in the mRNA expression of the estrogen receptor alpha correlated strongly with the change in mRNA level of the alpha1B-adrenoceptors. We presume that the expression of the alpha1B-adrenoceptors at 33-34 weeks in the pregnant human uterus is regulated by estrogen through the estrogen receptor alpha subtypes. |
| Databáze: | OpenAIRE |
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