Evaluation of the potential health risks of substances migrating from polycarbonate replacement baby bottles
| Autor: | Els Van Hoeck, Birgit Mertens, Adrian Covaci, Tara Vandermarken, Coraline Simon, Marie-Louise Scippo, Kersten Van Langenhove, Karine Vandermeiren, Heidi Demaegdt, Marc Elskens, Marie-Noelle Blaude, Joris Van Loco, Matthias Onghena |
|---|---|
| Přispěvatelé: | Chemistry, Earth System Sciences, Analytical, Environmental & Geo-Chemistry |
| Rok vydání: | 2016 |
| Předmět: |
Bisphenol A
Food contact materials Polymers Food Contamination Air Pollutants Occupational 010501 environmental sciences Endocrine Disruptors Toxicology 01 natural sciences Risk Assessment chemistry.chemical_compound 0404 agricultural biotechnology Phenols Plasticizers Medicine Humans European commission Benzhydryl Compounds 0105 earth and related environmental sciences Polycarboxylate Cement business.industry Pharmacology. Therapy Infant 04 agricultural and veterinary sciences General Medicine 040401 food science Bottle Feeding chemistry Human exposure business Plastics Food Science Potential toxicity |
| Zdroj: | Food and chemical toxicology |
| ISSN: | 1873-6351 0278-6915 |
| Popis: | Since the European Commission prohibited the use of bisphenol A in the production of polycarbonate (PC) baby bottles, many other materials have replaced PC for the manufacture of this type of food contact materials. In the present study, the potential migration risks associated with, these alternative materials were investigated. First, all substances were evaluated for endocrine disruptive (ED) activity by using different existing lists of (suspected) ED chemicals. Next, the potential non-ED risks were assessed. A distinction was made between migrants listed in Annex I of European Regulation 10/2011 and the unlisted substances (e.g. non-intentionally added substances). For the listed substances, concentrations in the migration solutions were compared to their respective specific migration limits (SML) (when applicable). Migration of all substances was shown to be below their SML. The unlisted substances were evaluated using toxicological information from previous evaluations, or if not available, by applying the Threshold of Toxicological Concern (ITC) approach. In case the estimated exposure to the unlisted substance exceeded the human exposure ITC value, a more indepth risk assessment was performed. Based on the results of both parts of the study, four baby bottles were considered of high concern because of the potential toxicity of migrating compounds. (C) 2016 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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