Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside
Autor: | Michele Curcio, Frank Bradke |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Central Nervous System Central nervous system Biology metabolism [Axons] Axonal Transport 03 medical and health sciences genetics [Nerve Regeneration] ddc:570 Peripheral Nervous System medicine Animals Humans Axon Cytoskeleton Growth cone physiology [Axons] Mammals Cell Biology growth & development [Peripheral Nervous System] growth & development [Central Nervous System] Axons genetics [Axonal Transport] Cns injury Nerve Regeneration 030104 developmental biology medicine.anatomical_structure nervous system Peripheral nervous system Axoplasmic transport Neuroscience Intracellular Developmental Biology |
Zdroj: | Annual review of cell and developmental biology 34(1), 495-521 (2018). doi:10.1146/annurev-cellbio-100617-062508 |
DOI: | 10.1146/annurev-cellbio-100617-062508 |
Popis: | After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons’ remarkable potential to grow during embryonic development and after an injury in the peripheral nervous system (PNS). Several intracellular mechanisms—including cytoskeletal dynamics, axonal transport and trafficking, signaling and transcription of regenerative programs, and epigenetic modifications—control axon regeneration. In this review, we describe how manipulation of intrinsic mechanisms elicits a regenerative response in different organisms and how strategies are implemented to form the basis of a future regenerative treatment after CNS injury. |
Databáze: | OpenAIRE |
Externí odkaz: |