Randomized, double-blind comparison of cefotaxime, cefoxitin, cefazolin or placebo as prophylaxis during gastric, small bowel or complicated biliary surgery
| Autor: | R. Blanchard, C. Yaffe, J. McLeod, J. Lertzman, T. J. Louie |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Cefotaxime Premedication Cefazolin Vagotomy Placebo Pyloroplasty Gastroenterology Sepsis Cefoxitin Random Allocation Double-Blind Method Internal medicine Intestine Small polycyclic compounds medicine Humans Pharmacology (medical) Digestive System Surgical Procedures Aged Pharmacology Clinical Trials as Topic business.industry Stomach Middle Aged medicine.disease Cephalosporins Surgery Biliary Tract Surgical Procedures Infectious Diseases Biliary tract Female business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 14:255-262 |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | In a double-blinded trial, 142 patients were randomized to receive placebo, cefazolin, cefoxitin or cefotaxime during high-risk gastroduodenal, biliary tract or small bowel surgery. Of the 125 evaluable patient trials, postoperative wound infection or intra-abdominal sepsis developed in 14/29 (48%) of placebo controls, 8/24 (33%) cefazolin, 7/37 (19%) cefoxitin, and in 2/35 (6%) of cefotaxime recipients. When patients undergoing vagotomy and pyloroplasty with prior cimetidine therapy were excluded, cefotaxime was superior to cefoxitin prophylaxis (2/26 versus 7/28, P = 0.014). Cefotaxime may be useful as a prophylactic agent in high-risk upper gastrointestinal surgery. |
| Databáze: | OpenAIRE |
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